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The neurologic phenotype in SCA8 BAC expansion but not BAC Regulate lines shown the pathogenicity from the (CTG-CAG)n enlargement. What's more, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the invention of intranuclear polyglutamine inclusions instructed that SCA8 pathogenesis consists of poisonous obtain-of-functionality